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AIMP1 / SCYE1 (aa137-149) Antibody (internal region)

Peptide-affinity purified goat antibody

  • IHC - AIMP1 /  SCYE1 (aa137-149) Antibody (internal region) AF3766a
    AF3766a (5 µg/ml) staining of paraffin embedded Human Pancreas. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
  • WB - AIMP1 /  SCYE1 (aa137-149) Antibody (internal region) AF3766a
    AF3766a (0.1 µg/ml) staining of Human Lymph Node lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q12904
Other Accession NP_004748.2, NP_001135888.1, 9255
Reactivity Human
Predicted Pig, Dog
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 34353 Da
Additional Information
Gene ID 9255
Other Names Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, Multisynthase complex auxiliary component p43, Endothelial monocyte-activating polypeptide 2, EMAP-2, Endothelial monocyte-activating polypeptide II, EMAP-II, Small inducible cytokine subfamily E member 1, AIMP1, EMAP2, SCYE1
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAIMP1 / SCYE1 (aa137-149) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AIMP1
Synonyms EMAP2, SCYE1
Function Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1- mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.
Cellular Location Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle, secretory vesicle. Secreted Endoplasmic reticulum. Golgi apparatus. Note=Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Also secreted in response to hypoxia and both apoptotic and necrotic cell death.
Research Areas
Citations (0)

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This antibody is expected to recognize both reported isoforms (NP_004748.2; NP_001135888.1). Reported variants represent identical protein: NP_004748.2, NP_001135887.1


Expression of AIMP1, 2 and 3, the scaffolds for the multi-tRNA synthetase complex, is downregulated in gastric and colorectal cancer. Kim SS, Hur SY, Kim YR, Yoo NJ, Lee SH. Tumori. 2011 May-Jun;97(3):380-5. PMID: 21789020

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$ 325.00
Cat# AF3766a
(40 western blots)
Availability: 7-10 days
Bulk Size
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