|Other Accession||NP_005867.3, 10290|
|Calculated MW||354289 Da|
|Other Names||Striated muscle preferentially expressed protein kinase, 18.104.22.168, Aortic preferentially expressed protein 1, APEG-1, SPEG, APEG1, KIAA1297|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||APEG1 / SPEG Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.|
|Cellular Location||Isoform 3: Nucleus.|
|Tissue Location||Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize isoform 1 only (NP_005867.3).
APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury. Hsieh CM, Yoshizumi M, Endege WO, Kho CJ, Jain MK, Kashiki S, de los Santos R, Lee WS, Perrella MA, Lee ME. J Biol Chem. 1996 Jul 19;271(29):17354-9. PMID: 8663449
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