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MEX3C (aa541-554) Antibody (internal region)

Peptide-affinity purified goat antibody

  • WB - MEX3C (aa541-554) Antibody (internal region) AF3772a
    AF3772a (0.2 µg/ml) staining of Mouse Testis (+/+ is wt, trp/trp is knock-down) lysate (35 µg protein in RIPA buffer). Data obtained by Dr. B. Lu, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA. Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q5U5Q3
Other Accession NP_057710.3, 51320, 240396 (mouse), 307271 (rat)
Reactivity Mouse
Predicted Human, Rat, Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 69366 Da
Additional Information
Gene ID 51320
Other Names RNA-binding E3 ubiquitin-protein ligase MEX3C, 6.3.2.-, RING finger and KH domain-containing protein 2, RING finger protein 194, MEX3C, RKHD2, RNF194
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMEX3C (aa541-554) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MEX3C
Synonyms RKHD2, RNF194
Function E3 ubiquitin ligase responsible for the post- transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.
Cellular Location Cytoplasm. Nucleus. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation
Tissue Location Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine
Research Areas
Citations (0)

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Identification and characterization of human
Mex-3 proteins, a novel family of evolutionarily conserved RNA binding proteins differentially localized to processing bodies. Buchet-Poyau K, Courchet J, Le Hir H, Séraphin B, Scoazec JY, Duret L, Domon-Dell C, Freund JN, Billaud M. Nucleic Acids Res. 2007;35(4):1289-300. PMID: 17267406

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$ 325.00
Cat# AF3772a
(40 western blots)
Availability: 7-10 days
Bulk Size
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