|Application ||WB, E|
|Other Accession||NP_057710.3, 51320, 240396 (mouse), 307271 (rat)|
|Predicted||Human, Rat, Pig, Dog, Cow|
|Calculated MW||69366 Da|
|Other Names||RNA-binding E3 ubiquitin-protein ligase MEX3C, 6.3.2.-, RING finger and KH domain-containing protein 2, RING finger protein 194, MEX3C, RKHD2, RNF194|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MEX3C (aa541-554) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin ligase responsible for the post- transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation|
|Tissue Location||Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine|
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Provided below are standard protocols that you may find useful for product applications.
Identification and characterization of human
Mex-3 proteins, a novel family of evolutionarily conserved RNA binding proteins differentially localized to processing bodies. Buchet-Poyau K, Courchet J, Le Hir H, Séraphin B, Scoazec JY, Duret L, Domon-Dell C, Freund JN, Billaud M. Nucleic Acids Res. 2007;35(4):1289-300. PMID: 17267406
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