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STRA8 (aa70-81) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q7Z7C7 |
| Other Accession | NP_872295.1, 346673, 500079 (rat) |
| Predicted | Human, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 36908 Da |
| Gene ID | 346673 |
|---|---|
| Other Names | Stimulated by retinoic acid gene 8 protein homolog, STRA8 {ECO:0000312|EMBL:AAP47163.1} |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | STRA8 (aa70-81) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STRA8 (HGNC:30653) |
|---|---|
| Function | Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, acts downstream of ZGLP1 as a key effector of the meiotic program: required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. In complex with MEIOSIN, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P70278}. Nucleus {ECO:0000250|UniProtKB:P70278}. Note=Shuttles between nucleus and cytoplasm. Nuclear export is XPO1-dependent {ECO:0000250|UniProtKB:P70278} |
| Tissue Location | Expressed specifically in testis and fetal ovaries. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Meiosis initiation in the human ovary requires intrinsic retinoic acid synthesis. Le Bouffant R, Guerquin MJ, Duquenne C, Frydman N, Coffigny H, Rouiller Fabre V, Frydman R, Habert R, Livera G. Hum Reprod. 2010 Oct;25(10):2579-90. PMID: 20670969
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