|Application ||WB, E|
|Other Accession||NP_061896.1, NP_001171753.1, 54496, 214572 (mouse), 361402 (rat)|
|Calculated MW||78459 Da|
|Other Names||Protein arginine N-methyltransferase 7, 2.1.1.-, Histone-arginine N-methyltransferase PRMT7, 18.104.22.168, [Myelin basic protein]-arginine N-methyltransferase PRMT7, 22.214.171.124, PRMT7, KIAA1933|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRMT7 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.|
|Cellular Location||Cytoplasm, cytosol. Nucleus|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_061896.1; NP_001171753.1).
PRMT7, a new protein arginine methyltransferase that synthesizes symmetric dimethylarginine. Lee JH, Cook JR, Yang ZH, Mirochnitchenko O, Gunderson SI, Felix AM, Herth N, Hoffmann R, Pestka S. J Biol Chem. 2005 Feb 4;280(5):3656-64. PMID: 15494416
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