|Other Accession||NP_995320.1, 148281, 54524 (mouse)|
|Predicted||Human, Mouse, Pig, Dog, Cow|
|Calculated MW||57325 Da|
|Other Names||Synaptotagmin-6, Synaptotagmin VI, SytVI, SYT6|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Synaptotagmin-6 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)- regulation of exocytosis in acrosomal reaction in sperm (By similarity).|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein Isoform 2: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Calcineurin-mediated dephosphorylation of synaptotagmin VI is necessary for acrosomal exocytosis. Castillo Bennett J, Roggero CM, Mancifesta FE, Mayorga LS. J Biol Chem. 2010 Aug 20;285(34):26269-78. PMID: 20551332
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