|Application ||WB, E|
|Other Accession||NP_058604.1, 6861, 53420 (mouse), 54309 (rat)|
|Predicted||Mouse, Pig, Dog, Cow|
|Calculated MW||42900 Da|
|Other Names||Synaptotagmin-5, Synaptotagmin V, SytV, SYT5|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Synaptotagmin-5 (aa 80-93) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)- dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Recycling endosome membrane; Single-pass membrane protein. Note=In mast cells, localizes to the endocytic recycling compartment.|
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Provided below are standard protocols that you may find useful for product applications.
Identification of a nonneuronal isoform of synaptotagmin. Hudson AW, Birnbaum MJ. Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):5895-9. PMID: 7597049
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