|Application ||WB, E|
|Other Accession||NP_006077.2, 10381, 22152 (mouse), 246118 (rat)|
|Predicted||Mouse, Rat, Pig, Cow|
|Calculated MW||50433 Da|
|Other Names||Tubulin beta-3 chain, Tubulin beta-4 chain, Tubulin beta-III, TUBB3, TUBB4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TUBB3 Antibody (internal region, near N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance.|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize isoform 1 (NP_006077.2) only.
Class III ?-tubulin expression in advanced-stage serous ovarian carcinoma effusions is associated with poor survival and primary chemoresistance. Hetland TE, Hellesylt E, Flørenes VA, Tropé C, Davidson B, Kærn J. Hum Pathol. 2011 Jul;42(7):1019-26. PMID: 21315408
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