|Application ||WB, E|
|Other Accession||NP_002181.1, 3605|
|Calculated MW||17504 Da|
|Other Names||Interleukin-17A, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8, IL17A, CTLA8, IL17|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL-17A (aa126-137) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).|
|Tissue Location||Restricted to activated memory T-cells.|
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Provided below are standard protocols that you may find useful for product applications.
Epidermal CCR6+ ?? T cells are major producers of IL-22 and IL-17 in a murine model of psoriasiform dermatitis. Mabuchi T, Takekoshi T, Hwang ST. J Immunol. 2011 Nov 15;187(10):5026-31. PMID: 21984702
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