Contactin 4 / Big-2 (mouse aa160-172) Antibody (internal region)
Peptide-affinity purified goat antibody
|Application ||WB, E|
|Other Accession||NP_001103219.1, NP_766592.2, 152330, 269784 (mouse), 116658 (rat)|
|Predicted||Human, Rat, Dog|
|Calculated MW||113454 Da|
|Other Names||Contactin-4, Brain-derived immunoglobulin superfamily protein 2, BIG-2, CNTN4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Contactin 4 / Big-2 (mouse aa160-172) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor. Secreted|
|Tissue Location||Mainly expressed in brain. Highly expressed in cerebellum and weakly expressed in corpus callosum, caudate nucleus, amygdala and spinal cord. Also expressed in testis, pancreas, thyroid, uterus, small intestine and kidney. Not expressed in skeletal muscle. Isoform 2 is weakly expressed in cerebral cortex.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_001103219.1; NP_766592.2). Reported variants represent identical protein: NP_766592.2, NP_001103221.1
BIG-2 mediates olfactory axon convergence to target glomeruli. Kaneko-Goto T, Yoshihara S, Miyazaki H, Yoshihara Y. Neuron. 2008 Mar 27;57(6):834-46. PMID: 18367085
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