Contactin 6 / NB-3 (mouse aa160-172) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | Q9UQ52 |
Other Accession | NP_059079.2, 27255, 53870 (mouse) |
Predicted | Mouse |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 113956 Da |
Gene ID | 27255 |
---|---|
Other Names | Contactin-6, Neural recognition molecule NB-3, hNB-3, CNTN6 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Contactin 6 / NB-3 (mouse aa160-172) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CNTN6 |
---|---|
Function | Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity). |
Cellular Location | Cell membrane; Lipid-anchor, GPI- anchor |
Tissue Location | Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord |
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Provided below are standard protocols that you may find useful for product applications.
References
Synaptic formation in subsets of glutamatergic terminals in the mouse hippocampal formation is affected by a deficiency in the neural cell recognition molecule NB-3. Sakurai K, Toyoshima M, Takeda Y, Shimoda Y, Watanabe K. Neurosci Lett. 2010 Apr 5;473(2):102-6. PMID: 20176085
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