Contactin 6 / NB-3 (mouse aa160-172) Antibody (internal region)
Peptide-affinity purified goat antibody
|Other Accession||NP_059079.2, 27255, 53870 (mouse)|
|Calculated MW||113956 Da|
|Other Names||Contactin-6, Neural recognition molecule NB-3, hNB-3, CNTN6|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Contactin 6 / NB-3 (mouse aa160-172) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity).|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
|Tissue Location||Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord|
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Provided below are standard protocols that you may find useful for product applications.
Synaptic formation in subsets of glutamatergic terminals in the mouse hippocampal formation is affected by a deficiency in the neural cell recognition molecule NB-3. Sakurai K, Toyoshima M, Takeda Y, Shimoda Y, Watanabe K. Neurosci Lett. 2010 Apr 5;473(2):102-6. PMID: 20176085
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