|Application ||WB, E|
|Other Accession||NP_003624.1, NP_001243505.1, 8507, 13803 (mouse), 294674 (rat)|
|Predicted||Human, Mouse, Pig, Dog, Cow|
|Calculated MW||66130 Da|
|Other Names||Ectoderm-neural cortex protein 1, ENC-1, Kelch-like protein 37, Nuclear matrix protein NRP/B, p53-induced gene 10 protein, ENC1, KLHL37, NRPB, PIG10|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ENC1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KLHL37, NRPB, PIG10|
|Function||Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism.|
|Cellular Location||Nucleus matrix. Cytoplasm. Cytoplasm, cytoskeleton|
|Tissue Location||Detected in fetal brain tissue, moderate expression in fetal heart, lung and kidney. Highly expressed in adult brain, particularly high in the hippocampus and amygdala, and spinal chord. Detectable in adult pancreas. May be down- regulated in neuroblastoma tumors|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_003624.1; NP_001243505.1). Reported variants represent identical protein: NP_001243503.1, NP_001243504.1, NP_003624.1.
Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level. Wang XJ, Zhang DD. PLoS One. 2009;4(5):e5492. PMID: 19424503
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