|Application ||WB, E|
|Other Accession||NP_006466.2, NP_001129406.1, NP_001129407.1, NP_001129408.1, 10631|
|Calculated MW||93314 Da|
|Other Names||Periostin, PN, Osteoblast-specific factor 2, OSF-2, POSTN, OSF2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||periostin Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.|
|Cellular Location||Golgi apparatus. Secreted, extracellular space, extracellular matrix. Note=Colocalizes with BMP1 in the Golgi.|
|Tissue Location||Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor Overexpressed in breast cancers.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize all reported isoforms (NP_006466.2; NP_001129406.1; NP_001129407.1; NP_001129408.1).
Periostin is induced in glomerular injury and expressed de novo in interstitial renal fibrosis. Sen K, Lindenmeyer MT, Gaspert A, Eichinger F, Neusser MA, Kretzler M, Segerer S, Cohen CD. Am J Pathol. 2011 Oct;179(4):1756-67. PMID: 21854746
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