|Application ||WB, E|
|Other Accession||NP_001805.3, 1075|
|Calculated MW||51854 Da|
|Other Names||Dipeptidyl peptidase 1, 220.127.116.11, Cathepsin C, Cathepsin J, Dipeptidyl peptidase I, DPP-I, DPPI, Dipeptidyl transferase, Dipeptidyl peptidase 1 exclusion domain chain, Dipeptidyl peptidase I exclusion domain chain, Dipeptidyl peptidase 1 heavy chain, Dipeptidyl peptidase I heavy chain, Dipeptidyl peptidase 1 light chain, Dipeptidyl peptidase I light chain, CTSC, CPPI|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||cathepsin C / DPP1 (aa238-252) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.|
|Tissue Location||Ubiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize isoform a (NP_001805.3) only.
Processing of human protryptase in mast cells involves cathepsins L, B, and C. Le QT, Gomez G, Zhao W, Hu J, Xia HZ, Fukuoka Y, Katunuma N, Schwartz LB. J Immunol. 2011 Aug 15;187(4):1912-8. PMID: 21742978
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