|Application ||WB, E|
|Other Accession||NP_001805.3, 1075|
|Calculated MW||51854 Da|
|Other Names||Dipeptidyl peptidase 1, 18.104.22.168, Cathepsin C, Cathepsin J, Dipeptidyl peptidase I, DPP-I, DPPI, Dipeptidyl transferase, Dipeptidyl peptidase 1 exclusion domain chain, Dipeptidyl peptidase I exclusion domain chain, Dipeptidyl peptidase 1 heavy chain, Dipeptidyl peptidase I heavy chain, Dipeptidyl peptidase 1 light chain, Dipeptidyl peptidase I light chain, CTSC, CPPI|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||cathepsin C / DPP1 (aa238-252) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.|
|Tissue Location||Ubiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize isoform a (NP_001805.3) only.
Processing of human protryptase in mast cells involves cathepsins L, B, and C. Le QT, Gomez G, Zhao W, Hu J, Xia HZ, Fukuoka Y, Katunuma N, Schwartz LB. J Immunol. 2011 Aug 15;187(4):1912-8. PMID: 21742978
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.