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cathepsin C / DPP1 (aa238-252) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P53634 |
| Other Accession | NP_001805.3, 1075 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 51854 Da |
| Gene ID | 1075 |
|---|---|
| Other Names | Dipeptidyl peptidase 1, 3.4.14.1, Cathepsin C, Cathepsin J, Dipeptidyl peptidase I, DPP-I, DPPI, Dipeptidyl transferase, Dipeptidyl peptidase 1 exclusion domain chain, Dipeptidyl peptidase I exclusion domain chain, Dipeptidyl peptidase 1 heavy chain, Dipeptidyl peptidase I heavy chain, Dipeptidyl peptidase 1 light chain, Dipeptidyl peptidase I light chain, CTSC, CPPI |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | cathepsin C / DPP1 (aa238-252) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CTSC |
|---|---|
| Synonyms | CPPI |
| Function | Thiol protease (PubMed:1586157). Has dipeptidylpeptidase activity (PubMed:1586157). Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids (PubMed:1586157). Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate (PubMed:1586157). Can act as both an exopeptidase and endopeptidase (PubMed:1586157). Activates serine proteases such as elastase, cathepsin G and granzymes A and B (PubMed:8428921). |
| Cellular Location | Lysosome. |
| Tissue Location | Ubiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize isoform a (NP_001805.3) only.
References
Processing of human protryptase in mast cells involves cathepsins L, B, and C. Le QT, Gomez G, Zhao W, Hu J, Xia HZ, Fukuoka Y, Katunuma N, Schwartz LB. J Immunol. 2011 Aug 15;187(4):1912-8. PMID: 21742978
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