|Application ||WB, E|
|Other Accession||NP_060741.3, NP_001231605.1, NP_001231607.1, 55258|
|Calculated MW||54116 Da|
|Other Names||Threonine synthase-like 2, TSH2, 4.2.3.-, Secreted osteoclastogenic factor of activated T-cells, SOFAT, THNSL2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||THNSL2 (aa192-204) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho- threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity).|
|Cellular Location||Isoform SOFAT: Secreted. Note=Secreted by activated T-cells via a calcineurin-independent pathway|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize all reported isoforms (NP_060741.3; NP_001231605.1; NP_001231607.1).
A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner. Rifas L, Weitzmann MN. Arthritis Rheum. 2009 Nov;60(11):3324-35. PMID: 19877052
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