|Application ||WB, IP, E|
|Other Accession||NP_002739.1, 5597, 50772 (mouse), 58840 (rat)|
|Predicted||Human, Rat, Pig, Dog, Cow|
|Calculated MW||82681 Da|
|Other Names||Mitogen-activated protein kinase 6, MAP kinase 6, MAPK 6, 188.8.131.52, Extracellular signal-regulated kinase 3, ERK-3, MAP kinase isoform p97, p97-MAPK, MAPK6, ERK3, PRKM6|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ERK3 / MAPK6 Antibody (internal region, near C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5.|
|Tissue Location||Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts|
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein (NP_056621.4; NP_081694.1).
The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology. Brand F, Schumacher S, Kant S, Menon MB, Simon R, Turgeon B, Britsch S,
Meloche S, Gaestel M, Kotlyarov A. Mol Cell Biol. 2012 Jul;32(13):2467-78. PMID: 22508986
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