UROD Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P06132 |
Other Accession | NP_000365.3, 7389 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 40787 Da |
Gene ID | 7389 |
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Other Names | Uroporphyrinogen decarboxylase, UPD, URO-D, 4.1.1.37, UROD |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | UROD Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | UROD (HGNC:12591) |
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Function | Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway (PubMed:14633982, PubMed:11069625, PubMed:21668429, PubMed:11719352, PubMed:18004775). Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme (PubMed:14633982, PubMed:11069625, PubMed:21668429, PubMed:11719352). In vitro also decarboxylates pentacarboxylate porphyrinogen I (PubMed:12071824). |
Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
References
Hepatoerythropoietic porphyria and familial porphyria cutanea tarda in Spanish patients: G281E mutation in the uroporphyrinogen decarboxylase gene. Darwich E, To-Figueras J, Badenas C, Herrero C. Arch Dermatol. 2010 Nov;146(11):1313-4. PMID: 21079081
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