|Application ||WB, E|
|Other Accession||NP_036566.1, 26503|
|Calculated MW||54640 Da|
|Other Names||Sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter, AST, Membrane glycoprotein HP59, Solute carrier family 17 member 5, Vesicular H(+)/Aspartate-glutamate cotransporter, SLC17A5|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||sialin / SLC17A5 (aa85-99) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential- dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Lysosome membrane; Multi-pass membrane protein|
|Tissue Location||Found in fetal lung and small intestine, and at lower level in fetal skin and muscle. In the adult, detected in placenta, kidney and pancreas. Abundant in the endothelial cells of tumors from ovary, colon, breast and lung, but is not detected in endothelial cells from the corresponding normal tissues|
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Provided below are standard protocols that you may find useful for product applications.
Functional characterization of vesicular excitatory amino acid transport by human sialin. Miyaji T, Omote H, Moriyama Y. J Neurochem. 2011 Oct;119(1):1-5. PMID: 21781115
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