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sialin / SLC17A5 (aa85-99) Antibody (internal region)

Peptide-affinity purified goat antibody

  • WB - sialin / SLC17A5 (aa85-99) Antibody (internal region) AF3945a
    AF3945a (1 µg/ml) staining of Human Placenta lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NRA2
Other Accession NP_036566.1, 26503
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 54640 Da
Additional Information
Gene ID 26503
Other Names Sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter, AST, Membrane glycoprotein HP59, Solute carrier family 17 member 5, Vesicular H(+)/Aspartate-glutamate cotransporter, SLC17A5
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautionssialin / SLC17A5 (aa85-99) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC17A5
Function Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential- dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva.
Cellular Location Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Lysosome membrane; Multi-pass membrane protein
Tissue Location Found in fetal lung and small intestine, and at lower level in fetal skin and muscle. In the adult, detected in placenta, kidney and pancreas. Abundant in the endothelial cells of tumors from ovary, colon, breast and lung, but is not detected in endothelial cells from the corresponding normal tissues
Research Areas
Citations (0)

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Functional characterization of vesicular excitatory amino acid transport by human sialin. Miyaji T, Omote H, Moriyama Y. J Neurochem. 2011 Oct;119(1):1-5. PMID: 21781115

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$ 325.00
Cat# AF3945a
(40 western blots)
Availability: 7-10 days
Bulk Size
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