|Application ||WB, E|
|Other Accession||NP_005177.2, 823|
|Calculated MW||81890 Da|
|Other Names||Calpain-1 catalytic subunit, 220.127.116.11, Calcium-activated neutral proteinase 1, CANP 1, Calpain mu-type, Calpain-1 large subunit, Cell proliferation-inducing gene 30 protein, Micromolar-calpain, muCANP, CAPN1, CANPL1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CAPN1 (aa468-481) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.|
|Cellular Location||Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding. In granular keratinocytes and in lower corneocytes, colocalizes with FLG and FLG2 (PubMed:21531719).|
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein: NP_001185797.1, NP_005177.2, NP_001185798.1.
Calpain-1 cleaves Rad21 to promote sister chromatid separation. Panigrahi AK, Zhang N, Mao Q, Pati D. Mol Cell Biol. 2011 Nov;31(21):4335-47. PMID: 21876002
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