|Application ||WB, E|
|Other Accession||NP_001815.2, 1158|
|Calculated MW||43101 Da|
|Other Names||Creatine kinase M-type, 22.214.171.124, Creatine kinase M chain, M-CK, Creatine kinase M-type, N-terminally processed, CKM, CKMM|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||creatine kinase M-type Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.|
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Muscle creatine kinase deficiency triggers both actin depolymerization and desmin disorganization by advanced glycation end products in dilated cardiomyopathy. Diguet N, Mallat Y, Ladouce R, Clodic G, Prola A, Tritsch E, Blanc J, Larcher JC, Delcayre C, Samuel JL, Friguet B, Bolbach G, Li Z, Mericskay M. J Biol Chem. 2011 Oct 7;286(40):35007-19. PMID: 21768101
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