|Application ||WB, E|
|Other Accession||NP_001230008.1, 126520|
|Calculated MW||36329 Da|
|Other Names||Inactive serine/threonine-protein kinase PLK5, Polo-like kinase 5, PLK-5, PLK5, PLK5P|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||polo-like kinase 5 (aa309-322) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation.|
|Cellular Location||Nucleus, nucleolus. Cytoplasm|
|Tissue Location||Expressed in the brain, neurons and glial cells. Also expressed in highly differentiated cells, such as the serous acini in the parotid gland, distal and proximal tubules of the kidney, tubules of the seminal gland, Kupffer cells and some hepatocytes in the liver, and some cells in the germinal center of lymph nodes (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. de Cárcer G, Escobar B, Higuero AM, García L, Ansón A, Pérez G, Mollejo M, Manning G, Meléndez B, Abad-Rodríguez J, Malumbres M. Mol Cell Biol. 2011 Mar;31(6):1225-39. PMID: 21245385
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