|Application ||WB, E|
|Other Accession||NP_003272.3, 7135|
|Calculated MW||21692 Da|
|Other Names||Troponin I, slow skeletal muscle, Troponin I, slow-twitch isoform, TNNI1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TNNI1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.|
|Tissue Location||Highest levels observed in human skeletal muscle (e.g. gastrocnemious muscle), differentiated cultures of primary human muscle cells and rhabdomyosarcoma cells cultured in low serum medium. Expressed in C2 muscle cell myoblasts and myotubes.|
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Provided below are standard protocols that you may find useful for product applications.
Identification of a region of troponin I important in signaling cross-bridge-dependent activation of cardiac myofilaments. Engel PL, Kobayashi T, Biesiadecki B, Davis J, Tikunova S, Wu S, Solaro RJ. J Biol Chem. 2007 Jan 5;282(1):183-93. PMID: 17099250
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