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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > TRIP4 / ASC1 (aa94-106) Antibody (internal region)
TRIP4 / ASC1 (aa94-106) Antibody (internal region)
Peptide-affinity purified goat antibody
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Application 
| E |
|---|---|
| Primary Accession | Q15650 |
| Other Accession | NP_057297.2, 9325, 56404 (mouse), 315769 (rat) |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 66146 Da |
| Gene ID | 9325 |
|---|---|
| Other Names | Activating signal cointegrator 1, ASC-1, Thyroid receptor-interacting protein 4, TR-interacting protein 4, TRIP-4, TRIP4 {ECO:0000312|EMBL:AAC41738.1, ECO:0000312|HGNC:HGNC:12310} |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRIP4 / ASC1 (aa94-106) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIP4 {ECO:0000312|EMBL:AAC41738.1, ECO:0000312|HGNC:HGNC:12310} |
|---|---|
| Function | Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription (PubMed:10454579, PubMed:25219498). May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions (PubMed:10454579, PubMed:25219498). Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF- kappa-B, SRF and AP1 (PubMed:12077347). Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347). May play a role in the development of neuromuscular junction (PubMed:26924529). May play a role in late myogenic differentiation (By similarity). Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773). |
| Cellular Location | Nucleus. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic under conditions of serum deprivation (PubMed:10454579). Colocalizes with NEK6 in the centrosome (PubMed:20873783). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Homeostatic and innate immune responses: role of the transmembrane glycoprotein CD98. Nguyen HT, Merlin D.Nguyen HT, Merlin D.Nguyen HT, Merlin D.Nguyen HT, Merlin D. Cellular and molecular life sciences : CMLS 2012 Sep 69 (18): 3015-26. PMID: 22460579
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$ 216.00
Cat# AF3977a
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