|Other Accession||NP_005903.2, 4160|
|Calculated MW||36943 Da|
|Other Names||Melanocortin receptor 4, MC4-R, MC4R|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MC4R Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Brain, placental, and gut tissues.|
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Provided below are standard protocols that you may find useful for product applications.
The immunizing peptide represents extracellular part of the protein
Constitutive cholesterol-dependent endocytosis of melanocortin-4 receptor (MC4R) is essential to maintain receptor responsiveness to ?-melanocyte-stimulating hormone (?-MSH). McDaniel FK, Molden BM, Mohammad S, Baldini G, McPike L, Narducci P, Granell S, Baldini G. The Journal of biological chemistry 2012 Jun 287 (26): 21873-90. PMID: 22544740
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