|Application ||WB, E|
|Other Accession||NP_001217.2, NP_116787.1, 839, 12368 (mouse), 83584 (rat)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||33310 Da|
|Other Names||Caspase-6, CASP-6, 184.108.40.206, Apoptotic protease Mch-2, Caspase-6 subunit p18, Caspase-6 subunit p11, CASP6, MCH2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Caspase 6 (alpha) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize reproted isoform alpha (NP_001217.2) only. The immunizing peptide overlaps phosphorylated serine 257 and therefore this antibody is not expected to recognize the phosphorylated protein.
Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization. Stanger K, Steffek M, Zhou L, Pozniak CD, Quan C, Franke Y, Tom J, Tam C, Elliott JM, Lewcock JW, Zhang Y, Murray J, Hannoush RN. Nature chemical biology 2012 Jul 8 (7): 655-60. PMID: 22683611
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