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contactin 1 Antibody (internal region)

Peptide-affinity purified goat antibody

  • WB - contactin 1 Antibody (internal region) AF4041a
    AF4041a (0.3 µg/ml) staining of Human Cerebellum (A), Mouse Brain (B) and Rat Brain (C) lysates (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • WB - contactin 1 Antibody (internal region) AF4041a
    AF4041a (0.3 µg/ml) staining of Pig Brain lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q12860
Other Accession NP_001834.2, NP_778203.1, NP_001242992.1, 1272, 12805 (mouse), 117258 (rat)
Reactivity Human, Mouse, Rat
Predicted Pig
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 113320 Da
Additional Information
Gene ID 1272
Other Names Contactin-1, Glycoprotein gp135, Neural cell surface protein F3, CNTN1
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautionscontactin 1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CNTN1
Function Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).
Cellular Location Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side
Tissue Location Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle
Research Areas
Citations (0)

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This antibody is expected to recognize all reported isoforms (NP_001834.2; NP_778203.1; NP_001242992.1). Reported variants represent identical protein: NP_001242993.1, NP_001242992.1.


A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells. Lamprianou S, Chatzopoulou E, Thomas JL, Bouyain S, Harroch S. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17498-503. PMID: 21969550

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$ 325.00
Cat# AF4041a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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