|Application ||WB, IHC, E|
|Other Accession||NP_001834.2, NP_778203.1, 1272, 12805 (mouse), 117258 (rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||113320 Da|
|Other Names||Contactin-1, Glycoprotein gp135, Neural cell surface protein F3, CNTN1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||contactin 1 (aa585-870) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).|
|Cellular Location||Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side|
|Tissue Location||Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize isoform 1 (NP_001834.2) and isoform 2 (NP_778203.1).
A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells. Lamprianou S, Chatzopoulou E, Thomas JL, Bouyain S, Harroch S. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17498-503. PMID: 21969550
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