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alpha-1-antitrypsin Antibody (internal region, near N-Term)

Peptide-affinity purified goat antibody

  • WB - alpha-1-antitrypsin Antibody (internal region, near N-Term) AF4044a
    EB1279(0.3 µg/ml) staining of Albumin-depleted Human Plasma lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01009
Other Accession NP_000286.3, 5265
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 46737 Da
Additional Information
Gene ID 5265
Other Names Alpha-1-antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, Short peptide from AAT, SPAAT, SERPINA1, AAT, PI
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautionsalpha-1-antitrypsin Antibody (internal region, near N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms AAT, PI
Function Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
Cellular Location Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum
Tissue Location Ubiquitous. Expressed in leukocytes and plasma.
Research Areas
Citations (0)

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The immunizing peptide represents the N terminus of the mature protein. Reported variants represent identical protein: NP_001121174.1, NP_001121179.1, NP_001121172.1, NP_001121177.1, NP_001121178.1, NP_001121176.1, NP_001121175.1, NP_000286.3, NP_00112117


Folding mechanism of the metastable serpin ?1-antitrypsin. Tsutsui Y, Dela Cruz R, Wintrode PL. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4467-72. PMID: 22392975

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$ 325.00
Cat# AF4044a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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