|Application ||WB, E|
|Other Accession||NP_009200.2, 6814|
|Calculated MW||67764 Da|
|Other Names||Syntaxin-binding protein 3, Platelet Sec1 protein, PSP, Protein unc-18 homolog 3, Unc18-3, Protein unc-18 homolog C, Unc-18C, STXBP3|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MUNC18C (aa514-527) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.|
|Cellular Location||Cytoplasm, cytosol. Cell membrane. Note=In platelets, predominantly cytosolic. Low amounts membrane-associated|
|Tissue Location||Megakaryocytes and platelets.|
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Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis. Jewell JL, Oh E, Ramalingam L, Kalwat MA, Tagliabracci VS, Tackett L, Elmendorf JS, Thurmond DC. The Journal of cell biology 2011 Apr 193 (1): 185-99. PMID: 21444687
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