|Application ||WB, E|
|Other Accession||NP_001728.1, 735|
|Calculated MW||63173 Da|
|Other Names||Complement component C9, Complement component C9a, Complement component C9b, C9|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||C9 (aa205-216) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells (PubMed:9634479, PubMed:9212048, PubMed:26841934). C9 is the pore- forming subunit of the MAC (PubMed:4055801, PubMed:26841934).|
|Cellular Location||Secreted. Target cell membrane; Multi- pass membrane protein. Note=Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore.|
|Tissue Location||Plasma (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9. Wickham SE, Hotze EM, Farrand AJ, Polekhina G, Nero TL, Tomlinson S, Parker MW, Tweten RK. The Journal of biological chemistry 2011 Jun 286 (23): 20952-62. PMID: 21507937
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