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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Goat Antibodies   >   alpha-2-macroglobulin Antibody (internal region)   

alpha-2-macroglobulin Antibody (internal region)

Peptide-affinity purified goat antibody

  • WB - alpha-2-macroglobulin Antibody (internal region) AF4074a
    AF4074a (0.5 µg/ml) staining of Human Albumin-depleted Serum lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01023
Other Accession NP_000005.2, 2
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 163291 Da
Additional Information
Gene ID 2
Other Names Alpha-2-macroglobulin, Alpha-2-M, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, A2M, CPAMD5
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautionsalpha-2-macroglobulin Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name A2M
Synonyms CPAMD5
Function Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Cellular Location Secreted.
Tissue Location Secreted in plasma.
Research Areas
Citations (0)

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Inhibition of beta2-microglobulin amyloid fibril formation by alpha2-macroglobulin. Ozawa D, Hasegawa K, Lee YH, Sakurai K, Yanagi K, Ookoshi T, Goto Y, Naiki H. The Journal of biological chemistry 2011 Mar 286 (11): 9668-76. PMID: 21216953

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$ 325.00
Cat# AF4074a
(40 western blots)
Availability: 7-10 days
Bulk Size
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