|Application ||WB, E|
|Other Accession||NP_004334.1, 811, 12317 (mouse), 64202 (rat)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||48142 Da|
|Other Names||Calreticulin, CRP55, Calregulin, Endoplasmic reticulum resident protein 60, ERp60, HACBP, grp60, CALR, CRTC|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||calreticulin Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).|
|Cellular Location||Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen. Note=Also found in cell surface (T cells), cytosol and extracellular matrix Associated with the lytic granules in the cytolytic T-lymphocytes|
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Provided below are standard protocols that you may find useful for product applications.
The polypeptide binding conformation of calreticulin facilitates its cell-surface expression under conditions of endoplasmic reticulum stress. Jeffery E, Peters LR, Raghavan M. The Journal of biological chemistry 2011 Jan 286 (4): 2402-15. PMID: 21075854
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