|Application ||WB, E|
|Other Accession||NP_001138632.1, NP_003281.1, 7171, 326618 (mouse), 24852 (rat)|
|Predicted||Rat, Pig, Dog, Cow|
|Calculated MW||28522 Da|
|Other Names||Tropomyosin alpha-4 chain, TM30p1, Tropomyosin-4, TPM4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Tropomyosin 4 / TPM4 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_001138632.1; NP_003281.1).
Tropomyosin 4 defines novel filaments in skeletal muscle associated with muscle remodelling/regeneration in normal and diseased muscle. Vlahovich N, Schevzov G, Nair-Shaliker V, Ilkovski B, Artap ST, Joya JE, Kee AJ, North KN, Gunning PW, Hardeman EC. Cell motility and the cytoskeleton 2008 Jan 65 (1): 73-85. PMID: 17968984
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