|Application ||WB, E|
|Other Accession||NP_001123476.1, NP_001093.1, NP_001123477.1, 87, 109711 (mouse), 81634 (rat)|
|Reactivity||Human, Mouse, Rat|
|Predicted||Pig, Dog, Cow|
|Calculated MW||103058 Da|
|Other Names||Alpha-actinin-1, Alpha-actinin cytoskeletal isoform, F-actin cross-linking protein, Non-muscle alpha-actinin-1, ACTN1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ACTN1 (aa596-609) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.|
|Cellular Location||Cytoplasm, cytoskeleton Cytoplasm, myofibril, sarcomere, Z line. Cell membrane. Cell junction. Cell projection, ruffle Note=Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and central reticular structures (By similarity).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize all reported isoforms (NP_001123476.1; NP_001093.1; NP_001123477.1).
Alpha-actinin 1 and alpha-actinin 4: contrasting roles in the survival, motility, and RhoA signaling of astrocytoma cells. Quick Q, Skalli O. Experimental cell research 2010 Apr 316 (7): 1137-47. PMID: 20156433
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