CAPG Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | P40121 |
Other Accession | NP_001738.2, NP_001243069.1, 822 |
Reactivity | Human |
Predicted | Dog |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 38499 Da |
Gene ID | 822 |
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Other Names | Macrophage-capping protein, Actin regulatory protein CAP-G, CAPG, AFCP, MCP |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CAPG Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CAPG |
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Synonyms | AFCP, MCP |
Function | Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. |
Cellular Location | Nucleus. Cytoplasm Melanosome. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P24452}. Cell projection, ruffle {ECO:0000250|UniProtKB:P24452}. Note=In macrophages, may be predominantly cytoplasmic. Nuclear localization was observed in fibroblasts. In macrophages, present at the membrane-cytoplasm interface. In activated macrophages, concentrated in the ruffles of the leading lamellipodia. {ECO:0000250|UniProtKB:P24452} |
Tissue Location | Macrophages and macrophage-like cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms (NP_001738.2; NP_001243069.1). Reported variants represent identical protein: NP_001243068.1, NP_001738.2.
References
The actin-capping protein CapG localizes to microtubule-dependent organelles during the cell cycle. Hubert T, Van Impe K, Vandekerckhove J, Gettemans J. Biochemical and biophysical research communications 2009 Feb 380 (1): 166-70. PMID: 19166812
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