|Application ||WB, E|
|Other Accession||NP_001738.2, NP_001243069.1, 822|
|Calculated MW||38499 Da|
|Other Names||Macrophage-capping protein, Actin regulatory protein CAP-G, CAPG, AFCP, MCP|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CAPG Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.|
|Cellular Location||Cytoplasm. Nucleus. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
|Tissue Location||Macrophages and macrophage-like cells.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_001738.2; NP_001243069.1). Reported variants represent identical protein: NP_001243068.1, NP_001738.2.
The actin-capping protein CapG localizes to microtubule-dependent organelles during the cell cycle. Hubert T, Van Impe K, Vandekerckhove J, Gettemans J. Biochemical and biophysical research communications 2009 Feb 380 (1): 166-70. PMID: 19166812
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