|Application ||WB, E|
|Other Accession||NP_005105.1, 9957|
|Calculated MW||35773 Da|
|Other Names||Heparan sulfate glucosamine 3-O-sulfotransferase 1, 188.8.131.52, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1, 3-OST-1, Heparan sulfate 3-O-sulfotransferase 1, h3-OST-1, HS3ST1, 3OST, 3OST1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HS3ST1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.|
|Cellular Location||Golgi apparatus lumen.|
|Tissue Location||Highly expressed in the brain and kidney and weakly expressed in the heart, lung and placenta|
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Provided below are standard protocols that you may find useful for product applications.
A conformational change in heparan sulfate 3-O-sulfotransferase-1 is induced by binding to heparan sulfate. Edavettal SC, Carrick K, Shah RR, Pedersen LC, Tropsha A, Pope RM, Liu J. Biochemistry 2004 Apr 43 (16): 4680-8. PMID: 15096036
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