|Application ||WB, E|
|Other Accession||NP_001677.2, 506, 11947 (mouse), 171374 (rat)|
|Reactivity||Human, Mouse, Rat, Pig|
|Calculated MW||56560 Da|
|Other Names||ATP synthase subunit beta, mitochondrial, 188.8.131.52, ATP5B, ATPMB, ATPSB|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATP5B (aa15162) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.|
|Cellular Location||Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Ectopic ATP synthase facilitates transfer of HIV-1 from antigen-presenting cells to CD4(+) target cells. Yavlovich A, Viard M, Zhou M, Veenstra TD, Wang JM, Gong W, Heldman E, Blumenthal R, Raviv Y. Blood 2012 Aug 120 (6): 1246-53. PMID: 22753871
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