|Application ||WB, E|
|Other Accession||NP_001141.2, 290|
|Calculated MW||109540 Da|
|Other Names||Aminopeptidase N, AP-N, hAPN, 184.108.40.206, Alanyl aminopeptidase, Aminopeptidase M, AP-M, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, gp150, CD13, ANPEP, APN, CD13, PEPN|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD13 / ANPEP Antibody (internal region, near C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||APN, CD13, PEPN|
|Function||Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytosol. Note=A soluble form has also been detected|
|Tissue Location||Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood- brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients|
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Provided below are standard protocols that you may find useful for product applications.
The X-ray crystal structure of human aminopeptidase N reveals a novel dimer and the basis for peptide processing. Wong AH, Zhou D, Rini JM. The Journal of biological chemistry 2012 Oct 287 (44): 36804-13. PMID: 22932899
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