|Application ||WB, E|
|Other Accession||NP_000500.2, NP_068656.2, 2266|
|Calculated MW||51512 Da|
|Other Names||Fibrinogen gamma chain, FGG|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Immunogen||Peptide with sequence C-KDTVQIHDITGKD, from the internal region of the protein sequence according to NP_000500.2; NP_068656.2.Please note the peptide is available for sale.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-fibrinogen gamma chain (aa166-178) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3- dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.|
|Tissue Location||Detected in blood plasma (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_000500.2; NP_068656.2).
The pleiotropic role of the fibrinogen gamma' chain in hemostasis. Uitte de Willige S, Standeven KF, Philippou H, Ariëns RA. Blood 2009 Nov 114 (19): 3994-4001. PMID: 19687509
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