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Goat Anti-SRRT / ARS2 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-SRRT / ARS2 Antibody AF4136a
    AF4136a (0.1 µg/ml) staining of Daudi (A) and Mouse Spleen (B) lysates (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BXP5
Other Accession NP_056992.4, NP_001122324.1, NP_001122325.1, NP_001122326.1, 51593, 83701 (mouse), 686980 (rat)
Reactivity Human, Mouse, Rat, Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 100666 Da
Additional Information
Gene ID 51593
Other Names Serrate RNA effector molecule homolog, Arsenite-resistance protein 2, SRRT, ARS2, ASR2
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Immunogen Peptide with sequence C-DPRAIVEYRDLDAPD, from the C Terminus of the protein sequence according to NP_056992.4; NP_001122324.1; NP_001122325.1; NP_001122326.1.Please note the peptide is available for sale.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-SRRT / ARS2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ARS2, ASR2
Function Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).
Cellular Location Nucleus, nucleoplasm. Cytoplasm. Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity).
Tissue Location Ubiquitously expressed.
Citations (0)

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This antibody is expected to recognize all reported isoform (NP_056992.4; NP_001122324.1; NP_001122325.1; NP_001122326.1).


Ars2 promotes proper replication-dependent histone mRNA 3' end formation. Gruber JJ, Olejniczak SH, Yong J, La Rocca G, Dreyfuss G, Thompson CB. Molecular cell 2012 Jan 45 (1): 87-98. PMID: 22244333

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$ 325.00
Cat# AF4136a
(40 western blots)
Availability: 3-5 days
Bulk Size
Seasonal Special on Bulk Order
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