|Application ||WB, E|
|Other Accession||NP_056992.4, NP_001122324.1, NP_001122325.1, NP_001122326.1, 51593, 83701 (mouse), 686980 (rat)|
|Reactivity||Human, Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||100666 Da|
|Other Names||Serrate RNA effector molecule homolog, Arsenite-resistance protein 2, SRRT, ARS2, ASR2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Immunogen||Peptide with sequence C-DPRAIVEYRDLDAPD, from the C Terminus of the protein sequence according to NP_056992.4; NP_001122324.1; NP_001122325.1; NP_001122326.1.Please note the peptide is available for sale.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-SRRT / ARS2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).|
|Cellular Location||Nucleus, nucleoplasm. Cytoplasm. Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity).|
|Tissue Location||Ubiquitously expressed.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize all reported isoform (NP_056992.4; NP_001122324.1; NP_001122325.1; NP_001122326.1).
Ars2 promotes proper replication-dependent histone mRNA 3' end formation. Gruber JJ, Olejniczak SH, Yong J, La Rocca G, Dreyfuss G, Thompson CB. Molecular cell 2012 Jan 45 (1): 87-98. PMID: 22244333
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