|Application ||WB, E|
|Other Accession||19017(mouse), 83516(rat), NP_037393.1|
|Predicted||Human, Mouse, Rat, Dog|
|Calculated MW||91027 Da|
|Other Names||PGC1A; PPARGC1A; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; LEM6; PGC-1(alpha); PGC-1v; PGC1; PPARGC1; PPAR gamma coactivator variant form; PPAR gamma coactivator-1; ligand effect modulator-6; peroxisome proliferative activated receptor; gamma, coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1, alpha|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-DGLFDDSEDESDK, from the internal region of the protein sequence according to NP_037393.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-PGC1A Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||LEM6, PGC1, PGC1A, PPARGC1|
|Function||Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.|
|Cellular Location||Isoform 1: Nucleus. Nucleus, PML body. Isoform B4-8a: Cytoplasm. Nucleus. Isoform 9: Nucleus|
|Tissue Location||Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects.|
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Provided below are standard protocols that you may find useful for product applications.
PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Handschin C, Kobayashi YM, Chin S, Seale P, Campbell KP, Spiegelman BM. Genes Dev. 2007 Apr 1;21(7):770-83.
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