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Goat Anti-CHRNA7 Antibody (internal region)
Purified Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, E |
|---|---|
| Primary Accession | P49582 |
| Other Accession | 11441(mouse), 25302(rat), NP_000737.1 |
| Reactivity | Rat |
| Predicted | Human, Mouse, Rat, Cow, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 |
| Calculated MW | 56632 Da |
| Gene ID | 11441 |
|---|---|
| Other Names | CHRNA7; cholinergic receptor, nicotinic, alpha 7; NACHRA7; a7 nicotinic acetylcholine receptor; alpha 7 neuronal nicotinic acetylcholine receptor; alpha-7 nicotinic cholinergic receptor subunit; alpha7 nicotinic receptor subunit; cholinergic receptor, nicotinic, alpha polypeptide 7; neuronal acetylcholine receptor protein, alpha-7 chain; neuronal nicotinic acetylcholine receptor alpha-7 subunit; nicotinic acetylcholine alpha-7 subunit; nicotinic acetylcholine receptor alpha7 subunit; nicotinic cholinergic receptor alpha 7 |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Peptide with sequence KRPGEDKVRPACQHKQ, from the internal region of the protein sequence according to NP_000737.1. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-CHRNA7 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Chrna7 |
|---|---|
| Synonyms | Acra7 |
| Function | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. |
| Cellular Location | Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=TMEM35A/NACHO promotes its trafficking to the cell membrane (PubMed:32783947). RIC3 promotes its trafficking to the cell membrane (By similarity) {ECO:0000250|UniProtKB:Q05941, ECO:0000269|PubMed:32783947} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice Ren K, King MA, Liu J, Siemann J, Altman M, Meyers C, Hughes JA, Meyer EM Neuroscience. 2007 Aug 10;148(1):230-7. Epub 2007 Jul 20
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