|Application ||IHC, E|
|Other Accession||11441(mouse), 25302(rat), NP_000737.1|
|Predicted||Human, Mouse, Rat, Cow, Dog|
|Calculated MW||56632 Da|
|Other Names||CHRNA7; cholinergic receptor, nicotinic, alpha 7; NACHRA7; a7 nicotinic acetylcholine receptor; alpha 7 neuronal nicotinic acetylcholine receptor; alpha-7 nicotinic cholinergic receptor subunit; alpha7 nicotinic receptor subunit; cholinergic receptor, nicotinic, alpha polypeptide 7; neuronal acetylcholine receptor protein, alpha-7 chain; neuronal nicotinic acetylcholine receptor alpha-7 subunit; nicotinic acetylcholine alpha-7 subunit; nicotinic acetylcholine receptor alpha7 subunit; nicotinic cholinergic receptor alpha 7|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence KRPGEDKVRPACQHKQ, from the internal region of the protein sequence according to NP_000737.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CHRNA7 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice Ren K, King MA, Liu J, Siemann J, Altman M, Meyers C, Hughes JA, Meyer EM Neuroscience. 2007 Aug 10;148(1):230-7. Epub 2007 Jul 20
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