|Application ||WB, E|
|Other Accession||NP_004818.2, NP_001244315.1|
|Calculated MW||72314 Da|
|Other Names||ABCG2; ATP-binding cassette, sub-family G (WHITE), member 2; ABC15; ABCP; BCRP; BCRP1; BMDP; CD338; CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1; ABC transporter; ATP-binding cassette sub-family G member 2; ATP-binding cassette transporter G2; breast|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-EPSKQDKPLIEK, from the internal region of the protein sequence according to NP_004818.2; NP_001244315.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-ABCG2 / BCRP Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ABCP, BCRP, BCRP1, MXR|
|Function||High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.|
|Cellular Location||Cell membrane; Multi- pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in placenta. Low expression in small intestine, liver and colon.|
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ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma. Singh RR, Kunkalla K, Qu C, Schlette E, Neelapu SS, Samaniego F, Vega F. Oncogene 2011 Dec 30 (49): 4874-86.
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