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Goat Anti-ABCG2 / BCRP Antibody (internal region)

Purified Goat Polyclonal Antibody

  • WB - Goat Anti-ABCG2 / BCRP Antibody (internal region) AF4157a
    AF4157a (0.1 µg/ml) staining of CACO-2 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UNQ0
Other Accession NP_004818.2, NP_001244315.1
Reactivity Human
Predicted Human
Host Goat
Clonality Polyclonal
Concentration 0.5
Calculated MW 72314 Da
Additional Information
Gene ID 9429
Other Names ABCG2; ATP-binding cassette, sub-family G (WHITE), member 2; ABC15; ABCP; BCRP; BCRP1; BMDP; CD338; CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1; ABC transporter; ATP-binding cassette sub-family G member 2; ATP-binding cassette transporter G2; breast
Format Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Immunogen Peptide with sequence C-EPSKQDKPLIEK, from the internal region of the protein sequence according to NP_004818.2; NP_001244315.1.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-ABCG2 / BCRP Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABCG2
Function High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
Cellular Location Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein
Tissue Location Highly expressed in placenta. Low expression in small intestine, liver and colon.
Research Areas
Citations (0)

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ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma. Singh RR, Kunkalla K, Qu C, Schlette E, Neelapu SS, Samaniego F, Vega F. Oncogene 2011 Dec 30 (49): 4874-86.

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$ 325.00
Cat# AF4157a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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