|Application ||WB, E|
|Other Accession||NP_612210.4, NP_963917.2, NP_001193939.1|
|Calculated MW||30762 Da|
|Other Names||CLEC12A; C-type lectin domain family 12, member A; CLL-1; CLL1; DCAL-2; MICL; C-type lectin domain family 12 member A; C-type lectin protein CLL-1; C-type lectin superfamily; C-type lectin-like molecule-1; dendritic cell-associated lectin 2; myeloid inhib|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-NPVQLGSTYFRE, from the C Terminus of the protein sequence according to NP_612210.4; NP_963917.2; NP_001193939.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CLEC12A / MICL Antibody (C Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CLL1, DCAL2, MICL|
|Function||Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein Note=Ligand binding leads to internalization|
|Tissue Location||Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages|
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Provided below are standard protocols that you may find useful for product applications.
The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses. Lahoud MH, Proietto AI, Ahmet F, Kitsoulis S, Eidsmo L, Wu L, Sathe P, Pietersz S, Chang HW, Walker ID, Maraskovsky E, Braley H, Lew AM, Wright MD, Heath WR, Shortman K, Caminschi I. Journal of immunology (Baltimore, Md. : 1950) 2009 Jun 182 (12): 7587-94.
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