|Application ||WB, E|
|Calculated MW||42203 Da|
|Other Names||CX3CL1; chemokine (C-X3-C motif) ligand 1; ABCD-3; C3Xkine; CXC3; CXC3C; NTN; NTT; SCYD1; fractalkine; neurotactin; C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; fractalkine; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fract|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-KTSEAPSTQDPST, from the internal region of the protein sequence according to NP_002987.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CX3CL1 / fractalkine Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FKN, NTT, SCYD1|
|Function||The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
Functional adhesiveness of the CX3CL1 chemokine requires its aggregation. Role of the transmembrane domain. Hermand P, Pincet F, Carvalho S, Ansanay H, Trinquet E, Daoudi M, Combadière C, Deterre P. The Journal of biological chemistry 2008 Oct 283 (44): 30225-34.
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