|Application ||WB, E|
|Calculated MW||42203 Da|
|Other Names||CX3CL1; chemokine (C-X3-C motif) ligand 1; ABCD-3; C3Xkine; CXC3; CXC3C; NTN; NTT; SCYD1; fractalkine; neurotactin; C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; fractalkine; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fract|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-KTSEAPSTQDPST, from the internal region of the protein sequence according to NP_002987.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CX3CL1 / fractalkine Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FKN, NTT, SCYD1|
|Function||Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 (PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed:9024663, PubMed:9177350).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas. Most abundant in the brain and heart|
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Functional adhesiveness of the CX3CL1 chemokine requires its aggregation. Role of the transmembrane domain. Hermand P, Pincet F, Carvalho S, Ansanay H, Trinquet E, Daoudi M, Combadière C, Deterre P. The Journal of biological chemistry 2008 Oct 283 (44): 30225-34.
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