|Application ||WB, E|
|Other Accession||NP_001768.1, NP_942088.1|
|Calculated MW||35214 Da|
|Other Names||CD47; CD47 molecule; IAP; MER6; OA3; CD47 antigen (Rh-related antigen, integrin-associated signal transducer); CD47 glycoprotein; Rh-related antigen; antigen identified by monoclonal antibody 1D8; antigenic surface determinant protein OA3; integrin associ|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-SNQKTIQPPRK, from the internal region (near C terminus) of the protein sequence according to NP_001768.1; NP_942088.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CD47 Antibody (internal region (near C terminus)) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain|
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Provided below are standard protocols that you may find useful for product applications.
Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo. Azcutia V, Stefanidakis M, Tsuboi N, Mayadas T, Croce KJ, Fukuda D, Aikawa M, Newton G, Luscinskas FW. Journal of immunology (Baltimore, Md. : 1950) 2012 Sep 189 (5): 2553-62.
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