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Goat Anti-ITGB2 / LFA-1 Antibody (internal region)

Purified Goat Polyclonal Antibody

  • WB - Goat Anti-ITGB2 / LFA-1 Antibody (internal region) AF4173a
    AF4173a (0.3 µg/ml) staining of K562 (A) and U937 (B) lysates (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P05107
Other Accession NP_000202.2
Reactivity Human
Predicted Human
Host Goat
Clonality Polyclonal
Concentration 0.5
Calculated MW 84782 Da
Additional Information
Gene ID 3689
Other Names ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7; cell surface adhesion glycoprotein LFA-1/CR3/P150, 959 beta subunit precursor); cell surface adhesion glycoproteins LFA-1/CR3/p150, 95 subunit beta; complement receptor C3 beta-subunit; complement receptor C3 subunit beta; integrin beta chain, beta 2; integrin beta-2; leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
Format Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Immunogen Peptide with sequence C-ETQEDHNGGQKQLS, from the internal region of the protein sequence according to NP_000202.2.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-ITGB2 / LFA-1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITGB2
Synonyms CD18, MFI7
Function Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha- D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module. Bolomini-Vittori M, Montresor A, Giagulli C, Staunton D, Rossi B, Martinello M, Constantin G, Laudanna C. Nature immunology 2009 Feb 10 (2): 185-94.

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$ 325.00
Cat# AF4173a
(40 western blots)
Availability: 7-10 days
Bulk Size
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