|Application ||WB, E|
|Calculated MW||84782 Da|
|Other Names||ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7; cell surface adhesion glycoprotein LFA-1/CR3/P150, 959 beta subunit precursor); cell surface adhesion glycoproteins LFA-1/CR3/p150, 95 subunit beta; complement receptor C3 beta-subunit; complement receptor C3 subunit beta; integrin beta chain, beta 2; integrin beta-2; leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-ETQEDHNGGQKQLS, from the internal region of the protein sequence according to NP_000202.2.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-ITGB2 / LFA-1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha- D/beta-2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module. Bolomini-Vittori M, Montresor A, Giagulli C, Staunton D, Rossi B, Martinello M, Constantin G, Laudanna C. Nature immunology 2009 Feb 10 (2): 185-94.
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