|Application ||WB, E|
|Calculated MW||29137 Da|
|Other Names||CD27; CD27 molecule; S152; S152. LPFS2; T14; TNFRSF7; Tp55; CD27 antigen; CD27L receptor; T cell activation antigen S152; T-cell activation antigen CD27; tumor necrosis factor receptor superfamily, member 7|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-QTLADFRQLPARTLS, from the internal region of the protein sequence according to NP_001233.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CD27 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Found in most T-lymphocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Soluble CD27-pool in humans may contribute to T cell activation and tumor immunity. Huang J, Jochems C, Anderson AM, Talaie T, Jales A, Madan RA, Hodge JW, Tsang KY, Liewehr DJ, Steinberg SM, Gulley JL, Schlom J. Journal of immunology (Baltimore, Md. : 1950) 2013 Jun 190 (12): 6250-8.
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