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Goat Anti-SERPINF1 / PEDF Antibody (internal region)
Purified Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P36955 |
| Other Accession | NP_002606.3 |
| Reactivity | Human |
| Predicted | Human, Pig, Cow, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 |
| Calculated MW | 46312 Da |
| Gene ID | 5176 |
|---|---|
| Other Names | SERPINF1; EPC-1; PEDF; PIG35; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; pigment epithelium-derived factor; proliferation-inducing protein 35; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Peptide with sequence C-KITGKPIKLTQVEHR, from the internal region of the protein sequence according to NP_002606.3. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-SERPINF1 / PEDF Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SERPINF1 |
|---|---|
| Synonyms | PEDF |
| Function | Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. |
| Cellular Location | Secreted. Melanosome. Note=Enriched in stage I melanosomes |
| Tissue Location | Retinal pigment epithelial cells and blood plasma. |
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Provided below are standard protocols that you may find useful for product applications.
References
pposing effects of pigment epithelium-derived factor on breast cancer cell versus neuronal survival: implication for brain metastasis and metastasis-induced brain damage. Fitzgerald DP et al. Cancer Res. 2012 Jan 1;72(1):144-53.
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