|Application ||WB, E|
|Other Accession||NP_001020330.1, NP_004346.1|
|Calculated MW||33516 Da|
|Other Names||CD74; DHLAG; HLADG; Ia-GAMMA; CD74 molecule, major histocompatibility complex, class II invariant chain; CD74 antigen; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); HLA-DR-gamma; Ia-associated invariant chain; MHC HLA-DR gamma chain; gamma chain of class II antigens|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-HSLEQKPTDAPPK, from the internal region of the protein sequence according to NP_001020330.1; NP_004346.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CD74 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane|
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CD74: a potential novel target for triple-negative breast cancer. Tian B, Zhang Y, Li N, Liu X, Dong J. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2012 Dec 33 (6): 2273-7.
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